University of Nottingham
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Preventing osteoporotic oractures by bone regeneration

porous microspheres

Injectable stem cell-carrying materials have the potential to treat and prevent fractures caused by osteoporosis and other bone-thinning diseases. 

We are developing experimental materials consisting of porous microspheres produced from calcium phosphates - a key component in bones – to be filled with stem cells extracted from the patient. 

 

The targeted therapy could offer a quick, easy and minimally-invasive treatment that is injected into areas considered to be at high-risk of fracture to promote bone regeneration.

The MIDOs project, supported by a £1.2m award from the National Institute for Health Research ( NIHR Invention for Innovation (i4i) Challenge Award), also supports the development of a prototype delivery device to inject these stem cell loaded microspheres to the sites of interest. We will investigate how well the materials stay in place once they have been injected inside the body. 

Research leads,  Dr Ifty Ahmed and  Professor Brigitte Scammell  (consultant orthopaedic surgeon) explained that the aim was to develop a preventive treatment option to address the growing issue of fractures occurring due to bone-thinning diseases, which is exacerbated due to the worldwide ageing population. 

Osteoporosis-related conditions affect some three million Britons, and cost the NHS over £1.73bn each year, according to the  National Osteoporosis Society

Ifty Ahmed said,

 We would advocate a national screening program, using a DEXA scan, which measures bone mineral density, to identify people at high risk of fracture due to osteoporosis.

If we could strengthen these peoples bone before they suffered from fractures, using a simple injection procedure, it would save people the pain and trauma of broken bones and associated consequences such as surgery and loss of independence.

 

The NIHR grant will also fund a Patient and Public Involvement study on the suitability of the technology, gauging the opinions and personal experience of people affected by osteoporosis as sufferers or carers, for example.

The project has already undertaken proof-of-concept work to test the feasibility of manufacturing the microsphere materials and lab work to ensure that stem cells attach and reside within these novel microsphere carriers.

The project team are working towards next phase pre-clinical trials.

Experts

Dr Ifty Ahmed

Associate Professor, Faculty of Engineering 

Professor Brigitte Scammell

Professor in Orthopaedics, Faculty of Medicine & Health Sciences