University of Nottingham
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Examining a pelvis

Biomaterials - 

Bone repair and tissue regeneration

 

Biomaterials present great opportunities for supporting the body’s own healing processes. Degradable and bioresorbable polymers are the next generation of medical implants and regenerative medicines, degrading in the body to leave healthy bone and tissue.

Prophylactic bone tissue regeneration for osteoporosis

porous microspheres

We are developing minimally invasive bone tissue regeneration for prophylactic treatment of osteoporosis, using bioresorbable spheres.  By targeting at-risk areas prone to fracture (eg hip and spine), we can help to prevent fractures through this prophylactic treatment.

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The bioresorbable spheres are made of calcium phosphate, which is the same make-up as bone. Filling the spheres with the body’s own stem cells, the calcium phosphates degrade leaving the stem cells to regenerate the patient’s bone.  Following £1.2m NIHR funding, we are now looking towards pre-clinical trials for this exciting technology.
 
Expert: Ifty Ahmed Read more about bone tissue regeneration

 

Injectable bone scaffolds

Kevin Shakesheff - Locate Therapeutics

Our spin-out company Locate Therapeutics has developed a family of injectable scaffolds using their TAOS® technology that solidify within the body and can be used to support tissue growth and precisely deliver cells or protein therapies via minimally invasive surgical procedures.

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The TAOS® 'injectable bone' material can be squirted into broken bones and hardens within minutes. The substance, which looks similar to toothpaste, fills bone defect areas to provide both mechanical integrity and a porous osteoconductive network for bone regeneration.

The polymer surfaces (and porous structure) support the migration of osteoblast progenitor cells and their differentiation into bone-forming secretory osteoblasts. As new bone is formed, the TAOS® polymer is resorbed from the site of implantation, thereby facilitating the restoration of normal bone contours and biomechanics.

 
Expert: Kevin Shakesheff Read more about the capabilities of TAOSTM  by Locate Therapeutics

 

Osteochondrial scaffolds for bone cartilage repair

We are developing osteochondrial scaffolds which anchor into the cartilage and bone region of a joint surface to promote the repair or replacement of bone cartilage. This is targeted at early stages of osteoarthritis and traumatic injury.

This technology is now at the stage of undertaking the first in vivo study.

Expert: Colin Scotchford 

Experts

Ifty Ahmed

Associate Professor, Faculty of Engineering

Davide de Focatiis

Associate Professor, Faculty of Engineering

David Grant

Professor of Materials Science and Head of Advanced Materials Research Group, Faculty of Engineering

Ed Lester

The Lady Trent Professor of Chemical Engineering, Faculty of Engineering

Andy Parsons

Senior Research Fellow, Faculty of Engineering

Alastair Campbell Ritchie

Assistant Professor, Faculty of Engineering

Chris Rudd

Professor of Mechanical Engineering and Pro Vice-Chancellor

Colin Scotchford

Associate Professor, Faculty of Engineering

Joel Segal

Associate Professor in Manufacturing Engineering, Faculty of Engineering

Kevin Shakesheff

Professor of Advanced Drug Delivery and Tissue Engineering, Faculty of Executive Office

Virginie Sottile

Associate Professor in Stem Cell Biology & Cell Differentiation, Faculty of Medicine & Health Sciences

Case studies

Prophylactic bone tissue regeneration treatment for osteoporosis

BENcH project - supporting fractured bones whilst healing

Biobones - biodegradable bone composite

Tissue repair and regeneration - Locate Therapeutics

Plastics Inside Us - Royal Society Summer Exhibition

Related Institutes, Centres and Groups

Advanced Materials Research Group

Biomaterials Discovery Programme

Regenerative Medicines and Cellular Therapies Research Division